Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C

AUTOR(ES)

Tanikawa, Aline Aki, Grotto, Rejane Maria Tommasini, Silva, Giovanni Faria, Ferrasi, Adriana Camargo, Sarnighausen, Valéria Cristina Rodrigues, Pardini, Maria Inês de Moura Campos

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

2017-02

RESUMO

Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. RESULTS: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. CONCLUSIONS: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.

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