Plasma Malondialdehyde in Coronary Patients and in “Normal” People at Rest and After Exercise

AUTOR(ES)

Avogaro, Pietro

RESUMO

The behavior of plasma lipid peroxides, expressed as plasma malondialdehyde, was studied in 27 patients with documented coronary artery disease and 17 volunteers without coronary artery disease (henceforth designated “normal”), after a standardized exercise on a bicycle ergometer. In the control group, the basal values of malondialdehyde were significantly lower than in coronary patients. Persons in the control group did not show any significant variation of malondialdehyde after exercise and recovery, whereas patients with coronary artery disease showed malondialdehyde levels significantly higher than the baseline, both after exercise and after recovery. In the control group, a significant inverse correlation between the malondialdehyde variations during the exercise and the total work produced was ten times lower than in coronary patients. It seems probable that the higher levels of lipid peroxides in these patients may leave some long-term unwanted effects. Furthermore, the increased values of lipid peroxides after exercise may be regarded as a possible trigger of fatal myocardial malfunction occurring during physical activity. Texas Heart Institute Journal 1986; 13:291-296)

Documentos Relacionados

• Excessive plasma dopamine increase at rest and during exercise after long-term beta-adrenoreceptor blockade in hypertensive patients.
• Arterial plasma histamine levels at rest, and during and after exercise in patients with asthma: effects of terbutaline aerosol.
• Strain Magnitude Assessed at Rest and During Stress Echocardiography in Patients with Normal Coronary Flow Reserve
• Haemodynamic studies at rest and during exercise in pulmonary stenosis after surgery.
• Plasma vasopressin and blood pressure. Studies in normal subjects and in benign essential hypertension at rest and after postural challenge.