Planejamento e síntese de intermediários para a obtenção de novos candidatos a protótipos de fármacos anticoagulantes desenhados a partir da infestina-4 / Planning and synthesis of intermediates for obtaining new candidates for prototypes of anticoagulants drawn from the infestin-4

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

15/09/2010

RESUMO

Thromboembolic disorders produce the majority of diseases affecting the heart, and are the third leading cause of death worldwide. Venous thromboembolism is a thromboembolic disorder that occurs in the venous circulation, is a disease of high prevalence and remains a major cause of morbidity and mortality in hospitalized patients undergoing major surgery, the fact that affect patients from the very young, disease free prior to the more elderly mean that it is a problem with major socioeconomic burden by as much as by absenteeism in hospital patients in productive age. This describes the planning and synthesis of intermediates for the collection of new derivatives guanidine drawn from the infestina-4, protein extracted from the stomach Barber Triatoma infestans, with potent inhibitory activity of factor XII. Factor XII acts of direct and indirect enzymatic cascades in four of our body and has an important contribution to the formation of pathological vascular thrombi. The previous study of molecular modeling justified based planning in the structural and the electrostatic infestin. Thus it is concluded that the synthesis of intermediates 25-28, were getting adequate yields of 88.0 and 92.0% for compounds 25 and 26 and 71.4 and 65.0% for compounds 27 and 28 respectively.

ASSUNTO(S)

anticoagulante fator xii infestina-4 farmacia 1. anticoagulante; 2. fator xii; 3. infestina-4 anticoagulant factor xii infestin-4

ACESSO AO ARTIGO

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