Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents
AUTOR(ES)
Cândido, Manuela C. L., Oliveira, Arquimedes M., Silva, Francisco O. N., Holanda, Alda K. M., Pereira, Walysson Gomes, Sousa, Eduardo H. S., Carneiro, Zumira A., Silva, Roberto S., Lopes, Luiz G. F.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2015-09
RESUMO
The development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers. Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy)2LX]n+, where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO+ and NO2− was investigated employing spectroscopic and electrochemical techniques. The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [RuIIH2O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea. The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.
Documentos Relacionados
- Study of the Reactivity of complex ions cis-[Ru (bpy)2(L) (NO)]n+ where L = imidazole, 1-metilimidazole, thiourea and sulfite
- Mecanismos celulares envolvidos no relaxamento da aorta de ratos induzidos pelo composto doador de óxido nítrico cis-[Ru(bpy)2(py)(NO2)](PF6)(RuBPY)
- Síntese, caracterização e estudo de reatividade dos complexos cis-[Ru(bpy)2(TU)(H2O)](PF6)2 E cis-[Ru(bpy)2(TU)(NO)](PF6)3
- Estudo cinÃtico da reaÃÃo dos complexos cis-[Ru(bpy)2ImN(NO)](PF6)3 e cis-[Ru(bpy)2SO3NO](PF6) com redutores biolÃgicos
- EPR and electrochemistry of [NH4]trans-[RuCl4(DMSO)(L)] complexes (L = DMSO, py ). X-ray molecular structure of [pyH][RuCl4(DMSO)(py)]