Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
AUTOR(ES)
Baratti, C.M., Boccia, M.M., Blake, M.G.
FONTE
Brazilian Journal of Medical and Biological Research
DATA DE PUBLICAÇÃO
2009-02
RESUMO
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".
Documentos Relacionados
- Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning
- Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning
- Memory reconsolidation for natural language processing
- Direct comparisons of the size and persistence of anisomycin-induced consolidation and reconsolidation deficits
- Memory reactivation and consolidation during sleep