Pharmacokinetics, protein binding, and extravascular distribution of ceftizoxime in normal subjects.

AUTOR(ES)

Peterson, L R

RESUMO

Thirteen normal subjects were given 2, 3, or 4 g of ceftizoxime intravenously in a prospective single-blinded study. Serum and urine concentrations were measured for 48 h. The beta-phase serum half-life ranged from 1.4 to 1.7 h. Approximately 100% of the agent was recovered unchanged in the urine over 48 h. Six of 13 subjects reported subjective complaints consisting of mild dizziness and moderate headache, all of which were transient. One subject also had a minimally elevated serum glutamic oxalacetic transaminase level 1 day after drug administration. Based on serum pharmacokinetics and serum protein binding determined in this investigation, unbound ceftizoxime appeared to distribute with the total body water.

Documentos Relacionados

• Pharmacokinetics, protein binding, and predicted extravascular distribution of moxalactam in normal and renal failure subjects.
• Pharmacokinetics of ceftazidime in normal and uremic subjects.
• Role of serum protein binding and multiple antibiotic doses in the extravascular distribution of ceftizoxime and cefotaxime.
• Vancomycin pharmacokinetics in normal and morbidly obese subjects.
• Moxalactam and cefazolin: comparative pharmacokinetics in normal subjects.