Pharmacokinetics of oral fleroxacin in male and premenopausal female volunteers.

AUTOR(ES)

Bertino, J S

RESUMO

The pharmacokinetics of oral fleroxacin were compared in men and premenopausal women. The total volume of distribution of the drug was significantly smaller in women in the single-dose trial. No difference in other pharmacokinetic parameters was noted. Since adverse events appear to occur in women more commonly than in men, dose-response studies of fleroxacin in women may be appropriate.

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