Pharmacokinetic interaction between itraconazole and rifampin in Yucatan miniature pigs.
AUTOR(ES)
Kaltenbach, G
RESUMO
The objective of this study was to examine the effects of rifampin on itraconazole pharmacokinetics, at steady state, in three Yucatan miniature pigs. Daily for 3 weeks, the pigs received 200 mg of itraconazole orally at the beginning of each meal, and for the following 2 weeks they received itraconazole orally combined with intravenous administration of rifampin at 10 mg/kg/day. Coadministration of rifampin resulted in an 18-fold decrease in the maximum concentration of itraconazole in serum, from 113.0 (standard deviation [SD] 17.2) to 6.2 (SD, 3.9) ng/ml and a 22-fold decrease in the area under the concentration-time curve, from 1,652.7 (SD, 297.7) to 75.6 (SD, 30.0) ng.h/ml. The active metabolite of itraconazole, hydroxyitraconazole, was undetectable. This study demonstrates that rifampin affects itraconazole kinetics considerably at steady state in this miniature-pig model, probably by inducing hepatic metabolism of itraconazole.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=163470Documentos Relacionados
- Pharmacokinetic interaction between itraconazole and ceftriaxone in Yucatan miniature pigs.
- Pharmacokinetic interaction between rifampin and zidovudine.
- Pharmacokinetic Interaction between Amprenavir and Rifabutin or Rifampin in Healthy Males
- Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs.
- Pharmacokinetic Interaction between Ritonavir and Indinavir in Healthy Volunteers
