Pharmacodynamic Interaction of Doxycycline and Artemisinin in Plasmodium falciparum

AUTOR(ES)

Sponer, Ulrike

FONTE

American Society for Microbiology

RESUMO

Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC50), EC90, and EC99 levels.

Documentos Relacionados

• Antimalarial Quinolines and Artemisinin Inhibit Endocytosis in Plasmodium falciparum
• In Vitro Interactions of Artemisinin with Atovaquone, Quinine, and Mefloquine against Plasmodium falciparum
• Carrier-Mediated Partitioning of Artemisinin into Plasmodium falciparum-Infected Erythrocytes
• Plasmodium falciparum-Based Bioassay for Measurement of Artemisinin Derivatives in Plasma or Serum
• Potentiation of Artemisinin Activity against Chloroquine-Resistant Plasmodium falciparum Strains by Using Heme Models