Phagosomal membranes of Mycobacterium bovis BCG-immune alveolar macrophages are resistant to disruption by Mycobacterium tuberculosis H37Rv.
AUTOR(ES)
Leake, E S
RESUMO
Data obtained in this study reaffirm that virulent Mycobacterium tuberculosis H37Rv has a potent phagosome-destroying capacity when ingested by normal alveolar macrophages. In contrast, Mycobacterium bovis BCG-immune alveolar macrophages are highly resistant to this virulence mechanism. BCG-immune sera incubated with BCG-immune alveolar macrophages did not increase resistance of BCG-immune alveolar macrophages as compared with the data obtained from experiments with normal sera. BCG-immune sera failed to confer resistance to normal alveolar macrophages against the phagosomal membrane-destroying H37Rv virulence mechanism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=263253Documentos Relacionados
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