Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy
AUTOR(ES)
Valentin, Antonio
FONTE
The National Academy of Sciences
RESUMO
We have identified a subset of CD56+CD3− human natural killer (NK) cells that express CD4 and the HIV coreceptors CCR5 and CXCR4. These cells can be productively infected in vitro by both CCR5- and CXCR4-using molecular clones of HIV-1 in a CD4-dependent manner. Analysis of HIV-infected persons showed that viral DNA is present in purified NK cells, and virus could be rescued from these cells after in vitro cultivation. Longitudinal analysis of the HIV-1 DNA levels in NK cells from patients after 1–2 years of highly active antiretroviral therapy indicated that NK cells remain persistently infected and account for a substantial amount of the viral DNA in peripheral blood mononuclear cells. These results demonstrate that a subset of non-T cells with NK markers are persistently infected and suggest that HIV infection of NK cells is important for virus persistence. The properties of the virus reservoir in these cells should be considered in attempts to further optimize antiretroviral therapies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=124520Documentos Relacionados
- Lipid profile of HIV-1 infected patients under highly active antiretroviral therapy
- Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy
- Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy
- Immunity to Human Immunodeficiency Virus (HIV) in Children with Chronic HIV Infection Receiving Highly Active Antiretroviral Therapy
- Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
