Perfil lipÃdico e correlaÃÃo entre concentraÃÃo e atividade de Lecitina: colesterol aciltransferase (LCAT) em plasma de pacientes com esquistossomose mansÃnica hepatointestinal e hepatoesplÃnica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Schistosomiasis, a disease caused by helminth Schistosoma mansoni affects about 200 million people worldwide. Due to deposition of eggs of the parasite in the liver, the disease may progress to a more mild, hepatointestinal (HI), for the most severe, hepatosplenic (HS). Previous studies show a relationship between lipid metabolism and the hepatosplenic form of the parasite, such as: reduction of plasma levels of total cholesterol, cholesterol ester and triglycerides, increased levels of phospholipids in patients and in non-human primates of the species and changes in Callithrix jacchus activity of lecithin: cholesterol acyltransferase (LCAT). The LCAT, enzyme esterificante of cholesterol, is a glycoprotein synthesized by the liver and is important in the metabolism of plasma lipoproteins, especially in the synthesis and maturation of circulating HDL. This work was evaluated the plasma concentration and activity of LCAT, and lipid profile of patients of schistosomiasis mansoni during HI and HS. The results show, compared to healthy subjects, a significant reduction in levels of total cholesterol, HDL cholesterol and cholesterol ester, and the activity and the concentration of LCAT in patients in the most critical stage of the disease. This decrease in catalytic activity of the enzyme may be associated with reduction in synthesis and / or secretion of the enzyme, since LCAT is produced in the liver, which is highly affected in schistosomiasis. The results suggest a direct correlation between the concentration of LCAT enzyme and its activity.

ASSUNTO(S)

esquistossomose mansÃnica schistosomiasis lcat activity concentraÃÃo lcat lcat concentration atividade lcat bioquimica lipid profile perfil lipÃdico

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