Peptidergic modulation of patterned motor activity in identified neurons of Helisoma
AUTOR(ES)
Murphy, A. D.
RESUMO
The neuroactive peptides SCPB (small cardioactive peptide B) and FMRFamide (Phe-Met-Arg-Phe-NH2), both originally isolated from molluscs, have potent modulatory effects upon the production of patterned motor activity in identified neurons (e.g., B5 and B19) in the buccal ganglia of the snail Helisoma. Such patterned motor activity has previously been shown to underlie feeding behavior. Micromolar concentrations of SCPB initiate patterned motor activity in quiescent ganglia and increase the rate of activity in ganglia that are spontaneously active. Micromolar concentrations of FMRFamide inhibit patterned motor activity in Helisoma buccal ganglia, and 10 μM FMRFamide completely suppresses such activity. In addition, there are both anti-SCPB-and anti-FMRFamide-immunoreactive neurons in Helisoma buccal ganglia. Our results suggest that peptides may play a prominent role in the regulation of feeding behavior in Helisoma.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=391326Documentos Relacionados
- Frequency-dependent release of peptide cotransmitters from identified cholinergic motor neurons in Aplysia.
- Multiple neuropeptides in cholinergic motor neurons of Aplysia: evidence for modulation intrinsic to the motor circuit.
- Crustacean peptidergic neurons in culture show immediate outgrowth in simple medium.
- Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neurites
- Dopaminergic neurons in the brain and dopaminergic innervation of the albumen gland in mated and virgin helisoma duryi (mollusca: pulmonata)