Peptide Chain Termination with Mammalian Release Factor
AUTOR(ES)
Goldstein, J. L.
RESUMO
We report a method for the in vitro study of peptide chain termination in mammals. A proteinaceous release factor has been isolated from rabbit reticulocyte extracts. This factor and a polyribonucleotide template containing the bases U and A stimulate the release of N-formylmethionine from mammalian [N-formylmethionyl-tRNAf·ribosome] intermediates. Our studies suggest that UAA is a terminator codon for mammalian cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283173Documentos Relacionados
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