Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients

AUTOR(ES)

Müller, Markus

FONTE

American Society for Microbiology

RESUMO

Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0.2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curveinfection/area under the concentration-time curveunaffected tissue = 0.99 ± 0.15 [mean ± standard error], n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue.

Documentos Relacionados

• Secretor state of patients with insulin dependent or non-insulin-dependent diabetes mellitus.
• A variant insulin promoter in non-insulin-dependent diabetes mellitus.
• Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
• Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.
• Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.