Pathogenesis of Influenza A (H5N1) Virus Infection in a Primate Model

AUTOR(ES)

Rimmelzwaan, G. F.

FONTE

American Society for Microbiology

RESUMO

Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

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