Pathogenesis of Human Parainfluenza Type 3 Virus Infection in Hamster Tracheal Organ Culture

AUTOR(ES)

Klein, Joel D.

RESUMO

Hamster tracheal organ culture was employed as a model for the study of the pathogenesis of human parainfluenza type 3 virus infection. It clearly supported replication of the virus over a 2-week period of time. Infected tracheal explants were examined with light, electron, and immunofluorescence microscopy. They exhibited specific cytopathologic alterations including nuclear swelling and chromatin margination, multinucleated syncytia and binucleated epithelial cells, and fibroblasts and chondrocytes. Focal destruction and denudation of the respiratory epithelium occurred in later stages of infection. Virus was detected in close association with cilia and was observed budding off the unit membrane of epithelial cells.

Documentos Relacionados

• Characterization of human parainfluenza virus type 3 persistent infection in cell culture.
• Diphtheria Pathogenesis in Guinea Pig Tracheal Organ Culture
• Bovine parainfluenza type 3 virus infection: ultrastructural aspects of viral pathogenesis in the bovine respiratory tract.
• Contribution of the Human Parainfluenza Virus Type 3 HN-Receptor Interaction to Pathogenesis In Vivo
• Mechanism of Interference Mediated by Human Parainfluenza Virus Type 3 Infection