Participação do oxido nitrico e do canal de potassio ATP-dependente na ereção peniana em cães / Role of adenosine triphosphate-dependent potassium chanels in canine penile erection

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Objective: To define the physiologic role and hemodynamic features of nitric oxide (NO) and the adenosine triphosphate (ATP)-dependent K+ (KATP)channel in canine penile erection. Material and Methods: Mongrel dogs were anesthetized, and penile erection was induced by electrical stimulation of the pelvic nerve. Changes in the intracavemous pressure (ICP) were measured with a transducer. Results: The basal ICP was 12.8 ::t 5.0 mmHg. Pelvic nerve stimulation (5 to 20 V, 5 to 15 Hz, for l-minute interval) significantly increased the ICP to 86.2 ::t 11.4 mmHg, (n = 5, P <0.05). Treatment with the NO synthase inhibitor L-NAME ~ -nitro-L-arginine methyl ester; 10 mglkg intravenously) abolished this increase (15.4 ::t 5.0 mmHg, n = 5, P <0.05). Intracavemous injection ofthe KATPchannel opener cromakalim (3 and 10 /lg) increased the ICP (103 ::t 14.4 mmHg and 106 ::t 12.1 mmHg, respectively, n=4). This response was abolished by the prior intracavemous injecton of the selective KATPchannel-specific blocker glybendamide (10 mg). Glibendamide did not affect the increase in ICP induced by electric stimulation of the pelvic nerve (88 ::t24.2 mmHg). Conclusions: Our results indicate that relaxation of canine cavemous smooth muscle and penile tumescence are mediated by NO. The failure of glybendamide to affect the increase in ICP induced by pelvic nerve stimulation suggest that ATP-dependente K+ channels probably do not play a physiologic role in canine penile erection

ASSUNTO(S)

pressão intracavernosa intracavernous pressure oxido nitrico nitric oxide penile induration penis - ereção

ACESSO AO ARTIGO

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