Partial nephrectomy for T3aN0M0 renal cell carcinoma: shall we step forward?

AUTOR(ES)

Peng, Ding, He, Zhi-song, Li, Xue-song, Tang, Qi, Zhang, Lei, Yang, Kai-wei, Yu, Xiao-teng, Zhang, Cui-jian, Zhou, Li-qun

FONTE

Int. braz j urol.

DATA DE PUBLICAÇÃO

2017-10

RESUMO

ABSTRACT Objectives: To evaluate the prognosis of non-metastatic T3a renal cell carcinoma (RCC) with partial nephrectomy (PN). Patients and Methods: We retrospectively evaluated 125 patients with non-metastatic T3a RCC. Patients undergoing PN and radical nephrectomy (RN) were strictly matched by clinic-pathologic characteristics. Log-rank test and Cox regression model were used for univariate and multivariate analysis. Results: 18 pair patients were matched and the median follow-up was 35.5 (10-86) months. PN patients had a higher postoperative eGFR than RN patients (P=0.034). Cancer-specific survival (CSS) and recurrence-free survival (RFS) did not differ between two groups (P=0.305 and P=0.524). On multivariate analysis, CSS decreased with positive surgical margin and anemia (both P <0.01) and RFS decreased with Furhman grade, positive surgical margin, and anemia (all P<0.01). Conclusions: For patients with non-metastatic pT3a RCC, PN may be a possible option for similar oncology outcomes and better renal function.

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