Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

AUTOR(ES)

Haskins, K

RESUMO

We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. In vivo, the clones mediate the destruction of islet, but not pituitary, grafts. Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients.

Documentos Relacionados

• Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.
• Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes.
• T-cell specific rearrangement of T-cell receptor beta transgenes in mice.
• Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1.
• Regulation of the Pancreatic Islet-Specific Gene BETA2 (neuroD) by Neurogenin 3