Pairing for Recombination in Lgv of Caenorhabditis Elegans: A Model Based on Recombination in Deficiency Heterozygotes
AUTOR(ES)
Rosenbluth, R. E.
RESUMO
The effect of deficiencies on recombination was studied in Caenorhabditis elegans. Heterozygous deficiencies in the left half of linkage group V [LGV(left)] were shown to inhibit recombination to their right. Fourteen deficiencies, all to the left of unc-46, were analyzed for their effect on recombination along LGV. The deficiencies fell into two groups: 10 ``major inhibitors'' which reduce recombination to less than 11% of the expected rate between themselves and unc-46; and four ``minor inhibitors'' which reduce recombination, but to a much lesser extent. All four minor inhibitors delete the left-most known gene on the chromosome, while six of the ten major inhibitors do not (i.e., these are ``internal'' deficiencies). Where recombination could be measured on both sides of a deficiency, recombination was inhibited to the right but not to the left. In order to explain these results we have erected a model for the manner in which pairing for recombination takes place. In doing so, we identify a new region of LGV, near the left terminus, that is important for the pairing process.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1203955Documentos Relacionados
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