Paclitaxel (Taxol)-Induced Killing of Leishmania major in Murine Macrophages
AUTOR(ES)
Doherty, T. Mark
FONTE
American Society for Microbiology
RESUMO
The antitumor drug paclitaxel (Taxol) has been demonstrated to be a lipopolysaccharide mimetic in murine macrophages. In this study, the capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and gamma interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO·)-dependent mechanism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108557Documentos Relacionados
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