Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

AUTOR(ES)

Marx, Camila, Gregianini, Tatiana Schaffer, Lehmann, Fernanda Kieling Moreira, Lunge, Vagner Ricardo, Carli, Silvia de, Dambros, Bibiana Paula, Tumioto, Gabriela Luchiari, Seadi, Claudete, Fonseca, Andre Salvador Kazantzi, Ikuta, Nilo

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

2013-05

RESUMO

The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

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