ORGAN-SPECIFIC ESTROGEN-INDUCED RNA SYNTHESIS RESOLVED BY DNA-RNA HYBRIDIZATION IN THE DOMESTIC FOWL*
AUTOR(ES)
Hahn, William E.
RESUMO
In the domestic fowl and other oviparous vertebrates, estrogens induce hepatic synthesis of yolk proteins. The oviduct also increases in size and produces ovalbumin when estrogens are administered. DNA-RNA hybridization assays indicate that within 105 minutes following treatment with estrone the liver of immature pullets contains most, if not all, of the liver RNA species that are present in the livers of the laying hen. Because of limitations of the nucleic acid hybridization technique, which remain to be clearly defined, it is not known whether the hepatic RNA populations in estrone-treated pullets and laying hens are completely homologous or differ in some important way. The results indicate that the genomic response in the avian liver to exogenous estrone is „normal” (relative to the laying hen) and further suggest that the hepatic response to estrogen is primarily pertinent to vitellinogenesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285962Documentos Relacionados
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