Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
Araujo, Renata Lins Fuentes de, Lyko, Karine de Fatima, Funke, Vaneuza Araujo Moreira, Torres-Pereira, Cassius Carvalho
Rev. Bras. Hematol. Hemoter.
DATA DE PUBLICAÇÃO
Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.