Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS
AUTOR(ES)
Lacy, Melinda K.
FONTE
American Society for Microbiology
RESUMO
Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89603Documentos Relacionados
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