Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital
AUTOR(ES)
Galisteu, Katia Jaira, Cardoso, Luciana Ventura, Furini, Adriana Antônia da Cruz, Schiesari Júnior, Arlindo, Cesarino, Claudia Bernardi, Franco, Célia, Baptista, Andrea Regina de Souza, Machado, Ricardo Luiz Dantas
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
2015-04
RESUMO
INTRODUCTION : In this study, clinical-laboratory and epidemiological characteristics are described for a group of 700 individuals with HIV (human immunodeficiency virus)/AIDS (acquired immunodeficiency syndrome) in the ART (antiretroviral therapy) era at a teaching hospital that provides a quaternary level of care, with an emphasis on opportunistic infections (OIs), co-infections and immune profile. METHODS : A retrospective cross-sectional study of AIDS cases was conducted from 1998 to 2008 by reviewing medical records from the Base Hospital/FUNFARME (Fundação Faculdade Regional de Medicina), São José do Rio Preto, São Paulo, Brazil. RESULTS: The individuals were 14 to 75 years of age, and 458 were males. Heterosexuals accounted for 31.1% of all patients. Eighty-three percent were on ART, and 33.8% of those presented difficulties with treatment adherence. OIs were analyzed from medical records, and Pneumocystis jiroveci pneumonia was the most prevalent, regardless of the LTCD4+ (TCD4+ Lymphocytes) levels. Individuals whose viral loads were ≥10,000 showed a 90% greater chance of neurotoxoplasmosis. For P. jiroveci pneumonia, neurotoxoplasmosis, esophageal candidiasis, pulmonary tuberculosis and neurocryptococcosis, the chances of infection were higher among patients with LTCD4+ levels below 200 cells/mm3. HIV/hepatitis C virus (HCV) and HIV/hepatitis B virus (HBV) co-infections were significantly associated with death. CONCLUSIONS : OIs remain frequent in the ART era even in populations where the access to medical care is considered satisfactory.
Documentos Relacionados
- Enteric parasitic infections in HIV/AIDS patients before and after the highly active antiretroviral therapy
- Survival of HIV‐infected patients in the intensive care unit in the era of highly active antiretroviral therapy
- Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study
- Ocular problems in brazilian patients with AIDS before and in highly active antiretroviral therapy (HAART) era
- MHC class II genotype and the control of viremia in HIV-1–infected individuals on highly active antiretroviral therapy