Opiate receptor: autoradiographic localization in rat brain.
AUTOR(ES)
Pert, C B
RESUMO
Opiate receptor sites in rat brain can be labeled in vivo by [3H]diprenorphine, a potent opiate antagoinst. Using techniques to minimize diffusion in fresh, frozen, unfixed brain, we have localized [3H]diprenorphine by autoradiography to visualize the distribution of opiate receptors. Silver grains indicative of the binding of labeled [3H]diprenorphine are discretely localized in numerous areas of the brain with very high densities in the locus coeruleus, the substantia gelatinosa of the spinal cord, and in clusters within the caudate-putamen, amygdala, and parts of the periventricular gray matter.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=431193Documentos Relacionados
- Autoradiographic localization of angiotensin II receptors in rat brain.
- Autoradiographic localization of relaxin binding sites in rat brain.
- Purification of the opiate receptor from rat brain.
- Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain.
- Opiate receptor: cooperativity of binding observed in brain slices.