On Measures of Gametic Disequilibrium
AUTOR(ES)
Lewontin, R. C.
RESUMO
Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the same range for all allelic frequencies, in fact, D' is not ``independent'' of allele frequency, and no measure with that general property is possible for the multilocus association problem. The insolubility of this problem arises from the ill-defined nature of general ``association.''
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1203562Documentos Relacionados
- Gametic Disequilibrium Measures: Proceed with Caution
- Multivariate Analysis of Gametic Disequilibrium in the Yanomama
- Gametic Disequilibrium in Multigenic Systems under Normalizing Selection
- Likelihood Analysis of Recombinational Disequilibrium in Multiple-Locus Gametic Frequencies
- The Effect That Genotyping Errors Have on the Robustness of Common Linkage-Disequilibrium Measures