Octamer-binding proteins in diverse hemopoietic cells.

AUTOR(ES)

Cockerill, P N

RESUMO

The immunoglobulin genes have B-cell-specific promoter and enhancer elements. The regulation of these elements is thought to be mediated to a large degree by the trans-activating factor oct-2, which binds the octamer element (ATTTGCAT). We have further examined the role of this octamer element in directing the lymphoid-specific expression of the immunoglobulin H enhancer. No direct relationship was found between the levels of expression of the Cmu gene and oct-2. Indeed, variable amounts of oct-2 were detected in all of the hemopoietic lineage cells tested in this study.

Documentos Relacionados

• A distinct octamer-binding protein present in malignant melanoma cells.
• The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.
• The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.
• Identification of an octamer-binding site in the human kappa light-chain enhancer.
• Identification of an octamer-binding site in the mouse kappa light-chain immunoglobulin enhancer.