Obtenção de membranas hidrofílicas a base de PVP (Poli N-vinil-2-pirrolidona) contendo alginato de sódio e nanocarga de pseudoboemita obtida pelo processo sol-gel

AUTOR(ES)

Isabella Tereza Ferro Barbosa

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

03/03/2011

RESUMO

The use of hydrogels combined with various additives in tissue regeneration and wound scarring, injuries and burnings has been an option in treatments of difficult scarring, infected-bleeding wounds, burnings and other diseases whose treatments, moist and sterilized resources are required. The hydrogels based on poly (N-vinyl-2-pyrrolidone) are membranes that form an effective barrier over the wound. It protects against the intrusion of external bacteria. It allows the passage in and out of oxygen and medicaments, since they are permeable to them. Pseudobohemite obtained by the sol-gel process are nanoparticles that present a highly superficial area, with expressive characteristic of bleeding absorption. They can adsorb large concentrations of medicaments released gradually in a site containing large amount of water, as it is the case of hydrogel membranes. The therapeutical attributes of hydrogel membranes are highly influenced by the presented concentration of water, about 85 to 90%, which determines the useful life and mechanical attributes of the product. Hydrogel based on PVP presents poor mechanical properties, which makes more difficult the handling of larger curatives. The objective of the study in obtaining hydrogel, based on PVP containing sodium alginate and nanoparticles of pseudobohemite obtained by sol-gel process consists in getting membranes with better mechanical properties and possible to incorporate suitable drugs to each kind of injures. In this study, were obtained and characterized membranes PVP based hydrogels (10%) containing sodium alginate nanoparticles pseudoboehmite concentrations of 1% and 3% respectively. The membranes were obtained by ionizing radiation dose of 25 kGy. The characterization of the membranes was performed by means of tensile tests and the physical-chemical gel fraction / fraction of the sun, swelling, dehydration isotherm is a function of time and thermal analysis. The results showed that the membranes of PVP containing sodium alginate showed higher degree of crosslinking (gel fraction higher), greater strength, greater degree of dehydration as a function of time and gel fraction higher water absorption compared to traditional membranes, only based PVP.

ASSUNTO(S)

hydrophilic membrane engenharia de materiais e metalurgica processo sol-gel poly (n-vinyl-2-pyrrolidone)-pvp pseudoboehmite membrana hidrofílica sol-gel process poli(n-vinil-2-pirrolidona)-pvp alginato de sódio pseudoboemita sodium alginate

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