O uso de células-tronco adultas em modelos experimentais de crises convulsivas. / The use of adult stem cells in experimental models of seizures.

AUTOR(ES)

Enéas Galdini Ferrazoli

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

26/05/2010

RESUMO

In Brazil, it is estimated that epilepsy affects from 2% of the population, about three million people at different ages and social classes. The use of antiepileptic drugs is the most common form of seizure control, although about 50- 70% of patients with epilepsy are refractory to medication. Because of difficulties in finding effective treatments, it is crucial to develop new therapies through new research fronts. Recent findings about the ability of pluripotent cells for regeneration of the adult nervous system allow to investigate the potential use of adult stem cells from bone marrow and other sources in neuronal regeneration and functional recovery of the epileptic brain. The aim of this study was to evaluate the potential of adult stem cells in protecting the induction of seizures, and possible decreased frequency of seizures. Using two experimental models of seizures, the maximum electroshock seizure acute model and the lithium-pilocarpine chronic model, and the transplantation of whole cells and mesenchymal bone marrow and skeletal muscle, we evaluated the potential of these cells to raise the seizure threshold and reverse the disease-induced damage. Our results indicated that the transplanting adult stem cells was not able to increase the seizure threshold in the acute model, as well as in the chronic model where the cells could not reduce spontaneous epileptic seizures. However, transplantation of adult stem cells is promising, indicating a reduction in mortality in the acute model. Moreover, in the chronic model we have shown the migration of transplanted cells to regions where there is massive neuronal death, indicating a potential treatment for a tissue recovery.

ASSUNTO(S)

bone marrow mesenchymal stem cell epilepsy electroconvulsive shock neurologia bone marrow mesenchymal stem cell epilepsy electroconvulsive shock

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