O fenômeno da tolerância oral e a regulação de células patogênicas Th17 no modelo de encefalomielite experimental auto-imune. / The oral tolerance phenomenon and the regulation of pathogenic Th17 cells during the EAE model.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

It has recently been shown the role of IL-17 secreting cells on the pathogenesis of multiple sclerosis and also in its model, EAE. Due to the secretion of this and other cytokines, the population so called Th17, promotes the disruption of the blood-brain barrier and the following infiltration of pathogenic cells into the CNS. In this context, in our work we used the oral tolerance phenomenon to evaluate its supressive capacity, more specifically over the Th17 cells. We showed that oral tolerated mice has a diminished production of IL-17 both in the periphery and in the CNS. Futhermore, we detected lower levels of CCL2 and IL-6 also from brain and spinal cord extracted mononucear cells at day 10th post-immunization. We were not able to detect differences on IL-4,5,10, 13, IL-12p70, TNF-a, e IFN-g between the groups. Thus, our results show that the oral tolerance phenomenon suppresses EAE findings, mainly due to a lower lymphoprolipherative response associated to a supression over the expansion of Th17 pathogenic T cells both in the periphery and inside the CNS.

ASSUNTO(S)

supressão th17 il-6 supression il-6 th17 eae eae oral tolerance tolerância oral

ACESSO AO ARTIGO

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