O emprego do potencial de longa latencia (P3) no diagnostico de complicações neurologicas e psiquicas do lupus eritematoso sistemico : comparação com a avaliação clinica e neuropsicologica

AUTOR(ES)
DATA DE PUBLICAÇÃO

1998

RESUMO

In an attempt to correlate neurological and neuropsychological findings with long-latency (endogenous) evoked potentials parameters, thirty-three female patients with a diagnosis of systemic lupus erythematosus were studied as to their visual auditory (brainstem), somatosensory (short latency and cortical) and long-latency (endogenous, P300) auditory evoked potentials and also submitted to a standardised neurological examination, to Folster s Mini-Mental State (MMS) and to Strub and Black s Mental Status Examination (MSE). 31% of the patients had abnormalities in their neurological examinations (1436% with multiple abnormalities); 937% had a MMS score below minimum for their educational level. There was no correlation between abnormal findings in the neurological examination and an abnormal MMS score. The finding of an abnormal visual or somatosensory evoked potential could predict an abnormal clinical examination. No correlation was found between an abnormal evoked potential of any modality - including age-corrected P300 latency - and MMS score corrected for educational level. Nevertheless a negative correlation was found between P300 latency and number of retrievals in a logical memory test. The use of the endogenous evoked potentials as a diagnostic tool in SLE may be justified by the high prevalence of neurological complications but not by the positive predictive value of the tests. The correlation between P300 latency and logical memory reinforces the hypothesis of a generator of this wave in both temporal regions

ASSUNTO(S)

potencial humano (eletrifisiologia) psicofisiologia eletrofisiologia atenção

ACESSO AO ARTIGO

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