Nutrição e AIDS : aspectos epidemiologicos do estado nutricional de pacientes portadores do HIV/AIDS, acompanhados no Hospital das Clinicas da UNICAMP

AUTOR(ES)
DATA DE PUBLICAÇÃO

2001

RESUMO

This study is a report on the nutritional status of individuals infected by mv /AIDS at various stages of the disease. It is an analytical, prospective longitudinal study of dynamic cohorts of individuals with HIV/AIDS, conducted ftom 1998 to 2000, at the Hospital das Clinicas,UNICAMP. This study consisted of310 patients who were each evaluated up to 4 times at four-month intervals. The assessments covered anthropometric, biochemical and immunologicalvariables. During folIow-up, most of the individuais in the here most ftequent categories of the classification of mv infection, which were A2(asymptomatic), A3, and C3(patients with AIDS), presented adequate weight, independent of the disease stage. The introduction of antiretroviral treatment modified the nutritional profile of mv /AIDS infected patients. Nowadays, malnutrition is less prevalent in patients treated with antiretroviral drugs (10%) in comparison with the antiretroviral perlod (60%). Qualitative changes have taken place and at present; there is a 30% prevalence of overweight and obesity. In this cohort study it was observed that concomitandy with the use of HAART, the immunological, clinical and nutritional condition improved and in 12 months the death probability due to AIDS was low (0.49%). However, these data demonstrate that malnutrition is related to a death risk 4 times greater in the case of AIDS than in other nutritional conditions. The multiple linear regression analysis demonstrated that jf the BMI of individuals infected with mv /AIDS was maintained at 22 to 23 Kglm2 (adequate weight) , the individuais presented less clinical, biochemical and immunological co-factors associated with immunodeficiency. The nutritional conditions did not affect the plasmatic levels of liposoluble vitamins and immunodeficiencywas also not found to be associated with the vitamin serum reduction. In order to prolong survival and to enhance the action of the drugs now being used in patients with mv/ AIDS, alterations like the redistribution of body fat (dislipidemia) should be routinely diagnosed and treated because they are part of the present spectrum of this infectious disease manifestations

ASSUNTO(S)

desnutrição obesidade antioxidantes

ACESSO AO ARTIGO

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