Novel Inhalational Murine Model of Invasive Pulmonary Aspergillosis

AUTOR(ES)

Sheppard, Donald C.

FONTE

American Society for Microbiology

RESUMO

We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1 × 103 to 3 × 103 conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.

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