Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing.

AUTOR(ES)

Koch, C

RESUMO

In a passive dendritic tree, inhibitory synaptic inputs activating ionic conductances with an equilibrium potential near the resting potential can effectively veto excitatory inputs. Analog interactions of this type can be very powerful if the inputs are appropriately timed and occur at certain locations. We examine with computer simulations the precise conditions required for strong and specific interactions in the case of a delta-like ganglion cell of the cat retina. We find some critical conditions to be that (i) the peak inhibitory conductance changes must be sufficiently large (i.e., approximately equal to 50 nS or more), (ii) inhibition must be on the direct path from the location of excitation to the soma, and (iii) the time course of excitation and inhibition must substantially overlap. Analog AND-NOT operations realized by satisfying these conditions may underlie direction selectivity in ganglion cells.

Documentos Relacionados

• Timing, Localization, and Persistence of Colonization by Segmented Filamentous Bacteria in the Neonatal Mouse Gut Depend on Immune Status of Mothers and Pups
• Role of methionine in bacterial chemotaxis: requirement for tumbling and involvement in information processing.
• Levenshtein distance for information extraction in databases and for natural language processing.
• Processing, localization, and requirement of human separase for normal anaphase progression
• Identification, localization, and role of fibronectin in cultured bovine endothelial cells.