Níveis plasmáticos de marcadores imunoinflamatórios na aterosclerose coronariana primária e na reestenose coronariana pós-angioplastia

AUTOR(ES)

Quadros, Alexandre Schaan de

DATA DE PUBLICAÇÃO

2010

RESUMO

Objective - To compare circulating plasma levels of immunoinflammatory markers in patients with known de novo coronary artery disease and patients with postangioplasty restenosis. Methods - Using enzymatic immunoabsorbent assay, we measured plasma levels of soluble interleukin-2 receptosr, tumor necrosis factor alpha, and soluble tumor necrosis alpha receptors I and II in 11 patients with restenosis postcoronary angioplasty (restenosis group), in 10 patients with primary atherosclerosis (de novo group) who were referred for coronary angiography because of stable or unstable angina, and in 9 healthy volunteers (control group). Levels of soluble interleukin-2 receptors were significantly higher in the de novo group compared with that in the restenosis and control groups. Levels were also higher in the restenosis group compared with that in the control group. Plasma levels of tumor necrosis alpha and receptor levels were significantly higher in the de novo group compared to with that in the restenosis and control groups, but levels in the restenosis group were not different from that in the controls. Conclusion – Coronary artery disease, either primary or secondary to restenosis, is associated with significant immunoinflammatory activity, which can be assessed by examining the extent of circulating plasma levels of inflammatory markers. Moreover, patients with de novo lesions appear to have increased inflammatory activity compared with patients with restenosis.

ASSUNTO(S)

análise de variância coronary artery disease angioplastia translumidal percutânea coronária inflammation tumor necrosis factor alpha marcadores biológicos estudos de casos e controles interleukin-2 estudo comparativo doença da artéria coronariana doença das coronárias receptores de interleucina-2 recidiva estatísticas não paramétricas fatores de necrose tumoral

Documentos Relacionados

• Trombocitopenia aguda pós-angioplastia coronária primária
• Pseudoaneurisma artéria femoral pós-angioplastia percutânea de artéria renal
• Níveis plasmáticos de Dímero D em pacientes com doença arterial coronariana
• Acurácia do teste ergométrico no diagnóstico da reestenose coronariana após angioplastia com implante de Stent convencional em pacientes assintomáticos
• Uso de duplo cateter-guia como auxílio para tratamento de perfuração coronariana durante angioplastia primária