Nifedipine and left ventricular function in beta-blocked patients.
AUTOR(ES)
Joshi, P I
RESUMO
We studied the acute effects of nifedipine on left ventricular function and haemodynamics at constant heart rate in patients on beta-blocker therapy. Nifedipine significantly depressed left ventricular peak dP/dt and peak dP/dt x P-1. Nifedipine also significantly reduced systemic vascular resistance: this was associated with decreased systolic blood pressure and increased left ventricular stroke output, with slight non-significant increases of ejection fraction and mean circumferential shortening velocity. There was no change in left ventricular end-diastolic pressure. This clinical study shows that nifedipine increases cardiac output in association with arterial dilatation despite evidence for a negative inotropic effect. Such intrinsic negative inotropic effects would normally be masked by compensatory sympathetic activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=482548Documentos Relacionados
- Heart rate dynamics during a treadmill cardiopulmonary exercise test in optimized beta-blocked heart failure patients
- Influence of intracoronary nifedipine on left ventricular function, coronary vasomotility, and myocardial oxygen consumption.
- Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy.
- Left Ventricular Diastolic Function in Essential Hypertensive Patients: Influence of Age and Left Ventricular Geometry
- Endoaneurysmorrhaphy for left ventricular aneurysm. Follow-up in 69 patients.
