New Allyldithiocarbimates: Synthesis, Structure and Antifungal Activity against Phakopsora pachyrhizi and Hemileia vastatrix

AUTOR(ES)

Vidigal, Antonio E. C.; Rubinger, Mayura M. M.; Silva, Lucas F. da; Zambolim, Laércio; Pereira, Arthur B. D.; Guilardi, Silvana; Souza, Rafael A. C.; Ellena, Javier

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2020-04

RESUMO

Twelve tetraphenylphosphonium allyldithiocarbimates were synthesized and fully characterized by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), infrared and nuclear magnetic resonance (NMR) spectroscopies. The spectroscopic data indicated that the allyldithiocarbimate anions present Z configuration, as confirmed by X-ray crystallography. These new compounds inhibited the germination of Phakopsora pachyrhizi and Hemileia vastatrix at very low doses, with IC50 (concentration to achieve 50% of inhibition of spore germination) values ranging from 0.028 to 0.166 mmol L-1, and IC90 (concentration to achieve 90% of inhibition of spore germination) values varying from 0.156 to 0.528 mmol L-1. Allyldithiocarbimate salts are lead compounds for the development of new antifungals for coffee leaf rust and Asian soybean rust, devastating plant diseases with limited control options.

Documentos Relacionados

• New aminoporphyrins bearing urea derivative substituents: synthesis, characterization, antibacterial and antifungal activity
• Synthesis, Spectroscopic Characterization, DFT Calculations and Preliminary Antifungal Activity of New Piperine Derivatives
• Antifungal compounds as a mechanism to control Hemileia vastatrix by antagonistic bacteria
• Synthesis, in vitro Antifungal Activity and Molecular Modeling Studies of New Mannich Bases Derived from Lawsone
• Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole