Neuropsychological characteristics of Huntington's disease carriers: a double blind study.

AUTOR(ES)

Rosenberg, N K

RESUMO

A cohort of 33 people at risk for Huntington's disease (HD), applying for genetic testing, were tested with a battery of neuropsychological tests covering attentional, visuospatial, learning, memory, and planning functions. A psychiatric rating scale, SCL-90R, was also applied, mainly as a control, since cognitive dysfunction could be ascribed to functional disorders as well as neurodegenerative processes. Self-rating did not indicate any psychiatric symptoms in carriers or non-carriers. However, significantly inferior cognitive functioning in the gene carriers was disclosed by the neuropsychological tests. Primarily, attentional, learning, and planning functions were affected. It is concluded that premorbid cognitive decline occurs in HD.

Documentos Relacionados

• Neuropsychological stability over two years in asymptomatic carriers of the Huntington's disease mutation.
• A double blind trial of sulpiride in Huntington's disease and tardive dyskinesia.
• Neuropsychological and neuroradiological correlates in Huntington's disease.
• Ethical and social issues in presymptomatic testing for Huntington's disease: a European Community collaborative study. European Community Huntington's Disease Collaborative Study Group.
• Huntington's Disease