Neisseria meningitidis antigens immune response study: toxoid as mice model adjuvant encapsulated in liposomes. / Estudo da imunogenicidade de antígenos de Neisseria meningitidis: utilização de toxóide como adjuvante, vetorizado em lipossomas, no modelo camundongo.

AUTOR(ES)

Tulio Nakazato da Cunha

DATA DE PUBLICAÇÃO

2008

RESUMO

N.meningitidis is diplococcus gram-negative strict human patogen that similarly to other bacteria are surrounded by external membrane with lipids, proteins (OMP) and LPS. It has been one of the main causes of the meningitidis and other invading infections in the world. This work searched to use STX2 toxoid of E.coli as adjuvant for a possible and future vaccine model and as antigenic stimulant proteins of the external membrane of meningococci (OMP) carried in liposomes. Differences in the production of IgG antibodies gotten between the mice each one of the 3 bleedings had been observed after but not how much to the avidity index. The new antigenic preparation unchained one high heading exactly after one year of 1st immunization stimulated the production of antibodies for other sites of linking and served as protection to the residual LPS of the processes with deoxicolate of the OMP diminishing toxicity of IM preparation reducing the aged risks for and very small children e also, in immunizations of long term with great advantage to the traditional systems.

ASSUNTO(S)

liposome antígenos de membrana externa de neisseria meningite lipossoma escherichia coli toxoid as adjuvant-antigen meningitis toxóide como adjuvante outer membrane antigens of neisseria mouse model escherichia coli modelo camundongos

Documentos Relacionados

• Toxicity and immunogenicity of Neisseria meningitidis lipopolysaccharide incorporated into liposomes.
• Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes.
• Study of immunogenicity of Neisseria lactamica antigens: use of monoclonal antibodies.
• Utilização de sílica mesoporosa como adjuvante em vacinas de vesícula de membrana externa de Neisseria meningitidis
• Type-specific antigens of group A Neisseria meningitidis: lipopolysaccharide and heat-modifiable outer membrane proteins.