Natural Thymocytotoxic Autoantibody and Reactive Antigen in New Zealand Black and Other Mice
AUTOR(ES)
Shirai, Toshikazu
RESUMO
Naturally occurring thymocytotoxic autoantibody (NTA) was detected by cytotoxic test in the sera of very young New Zealand Black mice (within 1 month after birth); the incidence was 100% at 3 months of age. Some mice from other strains also had NTA, but at an older age and with lower incidence and antibody titer. NTA had optimal activity at 4°C but was also strongly reactive at 37°C. It was cytotoxic for thymocytes of all strains of mice tested. Whereas only thymocytes were highly sensitive to NTA, the reactive antigen was demonstrated by absorption test in the thymus, lymph node, spleen, and brain of adult mice. It could be demonstrated only in the thymus of newborn mice.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389206Documentos Relacionados
- Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.
- Proceedings: Antigen catabolism in New Zealand and other strains of mice.
- Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.
- Prevention of Glomerulonephritis and Prolonged Survival in New Zealand Black/New Zealand White F1 Hybrid Mice Fed an Essential Fatty Acid-deficient Diet
- Chromosomal Abnormalities in Spleens of New Zealand Black Mice, A Strain Characterized by Autoimmunity and Malignancy