Nasal Immunization with Homogenate and Peptide Antigens Induces Protective Immunity against Trichinella spiralis
AUTOR(ES)
McGuire, Carolann
FONTE
American Society for Microbiology
RESUMO
Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=132977Documentos Relacionados
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