Myocardial remodeling and bioelectric changes in tachycardia-induced heart failure in dogs

AUTOR(ES)

Song, B., Wang, B.N., Chen, D.N., Luo, Z.G.

FONTE

Braz J Med Biol Res

DATA DE PUBLICAÇÃO

06/09/2013

RESUMO

In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic parameters were determined and the severity of the HF was evaluated by M-mode echocardiography. Changes in heart morphology were observed by scanning electron and light microscopy. Ventricular action potential duration (APD), as well as the 50 and 90% APD were measured in both groups. All dogs exhibited clinical symptoms of congestive HF after rapid right ventricular pacing for 3 weeks. These data indicate that rapid, right ventricular pacing produces a useful experimental model of low-output HF in dogs, characterized by biventricular pump dysfunction, biventricular cardiac dilation, and non-ischemic impairment of left ventricular contractility. Electrical and structural myocardial remodeling play an essential role in congestive HF progression, and should thus be prevented.

Documentos Relacionados

• Treatment of ventricular tachycardia-induced cardiomyopathy by transcatheter radiofrequency ablation.
• Reversibility of tachycardia-induced cardiomyopathy after radiofrequency ablation of incessant supraventricular tachycardia in infants.
• Frequency and predictors of tachycardia-induced cardiomyopathy in patients with persistent atrial flutter
• Myocardial phenotype changes in heart failure: cellular and subcellular adaptations and their functional significance
• Value of serial P wave changes in indicating left heart failure in myocardial infarction