Mutations in 23S rRNA in Helicobacter pylori Conferring Resistance to Erythromycin Do Not Always Confer Resistance to Clarithromycin

AUTOR(ES)

García-Arata, M. Isabel

FONTE

American Society for Microbiology

RESUMO

Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of >256 μg/ml, whereas mutants carrying A2143G had MICs ranging from ≤0.016 to >256 μg/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.

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