Mutants with Altered Sensitivity to a Calmodulin Antagonist Affect the Circadian Clock in Neurospora Crassa
AUTOR(ES)
Suzuki, S.
RESUMO
Two newly isolated mutant strains of Neurospora crassa, cpz-1 and cpz-2, were hypersensitive to chlorpromazine with respect to mycelial growth but responded differently to the drug with respect to the circadian conidiation rhythm. In the wild type, chlorpromazine caused shortening of the period length of the conidiation rhythm. Pulse treatment with the drug shifted the phase and inhibited light-induced phase shifting in Neurospora. By contrast to the wild type, the cpz-2 strain was resistant to these inhibitory effects of chlorpromazine. Inhibition of cpz-2 function by chlorpromazine affected three different parameters of circadian conidiation rhythm, namely, period length, phase and light-induced phase shifting. These results indicate that the cpz-2 gene must be involved in or related closely to the clock mechanism of Neurospora. By contrast, the cpz-1 strain was hypersensitive to chlorpromazine with respect to the circadian conidiation rhythm.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1207388Documentos Relacionados
- Isolation of Circadian Clock Mutants of NEUROSPORA CRASSA
- Complementation Analysis of Linked Circadian Clock Mutants of NEUROSPORA CRASSA
- Temperature Compensation of Circadian Period Length in Clock Mutants of Neurospora crassa1
- Light reception and circadian behavior in ‘blind’ and ‘clock-less’ mutants of Neurospora crassa
- Circadian Rhythms in NEUROSPORA CRASSA: Interactions between Clock Mutations
