Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression
AUTOR(ES)
Henkes, Luiz E
FONTE
BioMed Central
RESUMO
The corpus luteum is a unique organ, which is transitory in nature. The development, maintenance and regression of the corpus luteum are regulated by endocrine, paracrine and autocrine signaling events. Defining the specific mediators of luteal development, maintenance and regression has been difficult and often perplexing due to the complexity that stems from the variety of cell types that make up the luteal tissue. Moreover, some regulators may serve dual functions as a luteotropic and luteolytic agent depending on the temporal and spatial environment in which they are expressed. As a result, some confusion is present in the interpretation of in vitro and in vivo studies. More recently investigators have utilized mutant mouse models to define the functional significance of specific gene products. The goal of this mini-review is to identify and discuss mutant mouse models that have luteal anomalies, which may provide some clues as to the significance of specific regulators of corpus luteum function.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=293426Documentos Relacionados
- Recent advancements in corpus luteum development, function, maintenance and regression: Forum introduction
- Contribution of the immune system to follicle differentiation, ovulation and early corpus luteum formation
- Multiple roles of TNF super family members in corpus luteum function
- Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.
- Development, Function and Evolution of Teeth