Mutação pontual do códon 249 do TP53 no carcinoma hepatocelular / Mutation of TP53 codon 249 in the hepatocellular carcinoma

AUTOR(ES)

Jeronimo de Alencar Nogueira

DATA DE PUBLICAÇÃO

2008

RESUMO

TP53 249Ser mutation has been proved a molecular evidence for aflatoxin-related Hepatocellular Carcinoma (HCC) and is frequent in Africa and Asia. The aim of our study was to analyze the frequency of 249Ser mutation in HCC from Brazil. We studied 74 samples of paraffin embedded HCC. 249Ser mutation was analyzed by RFLP and sequencing. Presence of HBV DNA was determined by Real-Time PCR. 249Ser was found in 21/74 (28%) samples while HBV DNA was found in 13/74 (16%). Poorly differentiated HCC was more likely to have 249Ser mutation (OR = 2.415, IC = 1.001 - 5.824). The mean tumor size of 249Ser HCC was 9.4 cm versus 5.5cm on wild type (p=0.012). HBV DNA was not related with 249Ser. Results indicate that 249Ser is an important factor of HCC carcinogenesis in Brazil and is associated with large and poorly differentiated tumors.

ASSUNTO(S)

aflatoxin b1 genes p53 hepatocellular carcinoma genes p53 carcinoma hepatocelular mutação aflatoxina b1 mutation

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