Mouse neutrophils lack defensins.

AUTOR(ES)

Eisenhauer, P B

RESUMO

Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.

Documentos Relacionados

• Defensins. Natural peptide antibiotics of human neutrophils.
• Primary structures of three human neutrophil defensins.
• Susceptibility of Chlamydia trachomatis to protegrins and defensins.
• Direct inactivation of viruses by human granulocyte defensins.
• Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.